Inhalant use can lead to which of the following serious outcomes?

Inhalant use is associated with various significant health risks, and one of the most severe outcomes can indeed be comas or stupors. Inhalants depress the central nervous system, which can lead to a range of adverse effects, including loss of consciousness. This depressant effect can cause brain function to slow down dramatically, potentially resulting in a state of stupor or even coma if used in sufficient quantities or frequency. This outcome emphasizes the dangers associated with inhalant abuse, particularly as individuals may underestimate the risks involved.

The other options illustrate less likely outcomes of inhalant use. For example, increased physical endurance and enhanced cognitive clarity are not typical effects; rather, inhalants often impair physical and mental functions. Reduced social interaction might occur indirectly, as a result of harmful consequences of abuse, but it does not directly correlate as a serious immediate outcome compared to the risk of coma or stupor.