What is one of the major requirements for diagnosing Major Depressive Disorder?

The major requirement for diagnosing Major Depressive Disorder is the presence of at least five specific symptoms for a duration of two weeks. This is a core criterion outlined in the DSM-5-TR, which defines the episode of Major Depressive Disorder as marked by a significant change in mood and the ability to function.

The symptoms may include feelings of sadness, loss of interest, sleep disturbances, appetite changes, fatigue, feelings of worthlessness or excessive guilt, difficulty concentrating, and recurrent thoughts of death or suicide. To establish the diagnosis, these symptoms must cause clinically significant distress or impairment in social, occupational, or other important areas of functioning. The requirement for symptoms to be present for a continuous period of two weeks emphasizes the duration and intensity needed for the condition to be considered a Major Depressive Episode, rather than a temporary mood state.

The other options do not reflect the necessary criteria for this diagnosis. For instance, excessive energy levels would not align with the characteristics of depression, as this condition typically involves a lack of energy and motivation. Similarly, the presence of mania or hypomania indicates a bipolar disorder rather than Major Depressive Disorder. Lastly, while a history of substance abuse can impact mental health, it is not a diagnostic requirement for Major Depressive