Which of the following describes symptoms associated with the "With Anxious Distress" specifier?

The symptoms associated with the "With Anxious Distress" specifier are characterized by anxiety-related features that accompany a mood disorder. Among these features, feeling keyed up or tense is a notable symptom. This suggests an elevated level of anxiety, which can manifest as restlessness, feeling on edge, or an inability to relax.

In the context of the DSM-5-TR, "With Anxious Distress" indicates the presence of anxiety that significantly influences the mood disorder being diagnosed. This includes symptoms like tension, worry, and possibly difficulty concentrating due to anxiety.

Other symptoms and concerns listed in the options pertain to different clinical features. For example, loss of pleasure in activities relates more directly to depressive symptoms rather than anxiety. Marked psychomotor agitation also indicates restlessness, but it is more associated with specific mood disorders rather than the general feeling of being tense. Significant weight loss is a criterion often linked to depressive episodes rather than anxiety states, marking a differentiation from the anxiety symptoms. Thus, feeling keyed up or tense is accurately reflective of the anxious distress experienced in conjunction with mood disorders.