Which symptom is characteristic of a major depressive episode?

Feelings of worthlessness are indeed a characteristic symptom of a major depressive episode. According to the DSM-5-TR criteria for major depressive disorder, individuals experiencing a major depressive episode often report pervasive feelings of guilt or worthlessness. This symptom reflects the negative thought patterns that can accompany depression, significantly impacting an individual's self-esteem and self-perception.

In the context of a major depressive episode, these feelings are not just transient or situational; they persist and are often accompanied by other symptoms such as changes in sleep, appetite, and overall functioning. Recognizing this symptom is crucial for accurate diagnosis and treatment, as it can be a key factor in understanding the severity and impact of the depressive disorder on a person's life.